Wednesday Mar 11, 2026

Episode 137: Prolactin: Understanding High Levels & Prolactinomas with Romana

Prolactin: Understanding High Levels & Prolactinomas with Romana

Prolactin is most commonly known as the hormone responsible for breast milk production during pregnancy and postpartum. However, elevated prolactin levels outside of pregnancy or breastfeeding—known as hyperprolactinemia—are far more common than many people realize and can significantly impact cycles, fertility, and thyroid function.

Together Romana and I explore the complex relationship between prolactin, dopamine signaling, thyroid function, and the reproductive hormones that regulate ovulation and menstrual cycles. We also discuss how chronic stress, inflammation, and underlying endocrine dysfunction can disrupt prolactin regulation.

 

A few things we chat about in this episode 👇👇👇

  • What prolactin is, and when elevated levels are expected
  • Why prolactin may be elevated when you are not pregnant or breastfeeding
  • How elevated prolactin impacts ovulation, progesterone production, and cycle regularity
  • The relationship between prolactin, dopamine, and reproductive signaling
  • The relationship between thyroid function, stress and prolactin
  • When to suspect a prolactinoma, and which lab ranges matter
  • How prolactin influences immune function and inflammation
  • Treatment approaches for hyperprolactinemia and prolactinomas

 

Important show links 👇👇👇

 

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